The PathHunter® Aflibercept Bioassay HS Kit is an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. VEGF-165) based activation of KDR/KDR Kinase activity via detection of Dimerization. The included cells overexpress ProLink-tagged KDR/KDR and EA-tagged. Activation of KDR/KDR stimulates the recruitment of and produces EFC signal. This bioassay has been optimized and qualified with the marketed biologic drug, Eylea® which is not provided in the bioassay kit. Eyelea® is a registered trademark of Regeneron Pharmaceutical, Inc. Bioassay kits are a convenient format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. The HS kit has been optimized to deliver reproducible results with lower variability.
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Kinase Insert Domain Receptor, FLK1, CD309, VEGFR, VEGFR2
Potency; Commercial Release & Stability
Store in vapor phase of liquid nitrogen.
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Eylea® is a registered trademark of Regeneron Pharmaceuticals, Inc.
PathHunter® Aflibercept Bioassay HS Kit
The PathHunter® Aflibercept Bioassay HS Kit is an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses ligand (e.g. VEGF-165) based activation of KDR/KDR Kinase activity via detection of Dimerization.
View bioassay qualification data.