| Biological Information | |
|---|---|
| Background Information: | PAK5 is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
GenBank NM_020341 |
| Target Class: | Kinase |
| Accession Number: | NM_020341.2; NM_177990.1 |
| Target Name: | PAK5 |
| Target Aliases: | PAK7, PAK-5, PAK5, MGC26232, KIAA1264, PAK-7 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PAK5, active
N-terminal 6His-tagged recombinant, human PAK5 amino acids 425-end. PAK5 is also known as PAK7.
Datasheets
14-699x Datasheet
View Document