PAK4, active

Background Information:

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. GenBank NM_005884

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

PAK4

Protein Aliases:

p21-activated kinase 4|PAK-4

Accession Number:

NM_005884.2

UniProt Number:

O96013

Gene Name:

PAK4

Gene ID:

10298

Target Species:

Human