p38alpha/SAPK2a, unactive

Background Information:

p38alpha/SAPK2a Protein is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP Kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. GenBank L35264

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

p38alpha (SAPK2A)

Protein Aliases:

p38 MAP kinase

Accession Number:

NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1

UniProt Number:

Q16539

Gene Name:

MAPK14

Gene ID:

1432

Gene Aliases:

PRKM14|p38|PRKM15|CSBP|CSBP1|CSBP2|CSPB1|MXI2|SAPK2A

Target Species:

Human