Biological Information

Background Information:

N-terminal GST-tagged recombinant, human full length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione-agarose. Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

p38alpha (SAPK2A)

Protein Aliases:

p38 MAP kinase

Accession Number:

NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1

UniProt Number:

Q16539

Gene Name:

MAPK14

Gene ID:

1432

Gene Aliases:

PRKM14|p38|PRKM15|CSBP|CSBP1|CSBP2|CSPB1|MXI2|SAPK2A

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -20°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology