p38β2/SAPK2b2, unactive

Background Information:

MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

p38beta (SAPK2)

Protein Aliases:

MAPK 11|Mitogen-activated protein kinase p38 beta|MAP kinase p38 beta|p38b|Stress-activated protein kinase 2b|SAPK2b|p38-2

Accession Number:

Y14440

UniProt Number:

Q15759

Gene Name:

MAPK11

Gene ID:

5600

Gene Aliases:

p38-2|p38Beta|SAPK2|PRKM11|SAPK2B

Target Species:

Human