| Biological Information | |
|---|---|
| Background Information: | NSD1 (Nuclear receptor-binding SET domain protein 1) is a histone methyltransferase that belongs to the SET domain-containing protein family. NSD1 specifically targets histone H3 at lysine 36 (H3K36), and catalyzes its mono-, di-, and tri-methylation, leading to changes in chromatin structure and gene expression.
NSD1 has been implicated in the regulation of development and growth, including the regulation of body size and brain development. It has also been shown to play a role in the development of several types of cancer, including leukemia and solid tumors. In addition, mutations in the NSD1 gene have been associated with Sotos syndrome, a rare genetic disorder characterized by overgrowth, developmental delay, and intellectual disability.
NSD1 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | NSD1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
NSD1
Recombinant human NSD1 amino acids 1810-2120.
Datasheets
EPI041 Datasheet
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