NIM1 (Never in mitosis A-related kinase 1) is a serine/threonine protein kinase that belongs to the NIMA-related kinase (NEK) family of kinases. It is involved in a variety of cellular processes, including regulation of the cell cycle, DNA damage response, and apoptosis. Research has suggested that NIM1 plays a role in several diseases, including cancer, neurodegenerative diseases, and inflammation. In cancer, NIM1 has been shown to promote tumor growth and survival, and inhibition of NIM1 has been suggested as a potential cancer therapy. In neurodegenerative diseases, NIM1 has been implicated in the regulation of neuronal survival and degeneration, and alterations in NIM1 expression have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. Additionally, NIM1 has been implicated in the regulation of the immune response, making it a potential target for the treatment of inflammatory diseases.
Drug Discovery & Development
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