MRCKalpha, active

Background Information:

MRCKα Protein is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. GenBank NM_003607

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

MRCKalpha

Protein Aliases:

myotonic dystrophy kinase-related Cdc42-binding kinase

Accession Number:

NM_003607.3; NM_014826.4

UniProt Number:

Q5VT25

Gene Name:

CDC42BPA

Gene ID:

8476

Gene Aliases:

MRCKA|PK428|FLJ23347|KIAA0451|MRCK

Target Species:

Human