MAP4K4, active

N-terminal GST tagged and C-terminal 6His tagged, recombinant, human MAP4K4 amino acids 1-328, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography.

Catalog #: 15-012

389.002,969.00


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Biological Information
Background Information:
MAP4K4 is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Target Class:
Kinase
Family:
Ser/Thr Kinase
Accession Number:
NM_004834.4
Target Name:
MAP4K4
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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Datasheets

15-012x Datasheet

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