KILR® SKBR3 Cell Pool

The KILR® SKBR3 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments via ADCC, CDC, and ADCP.

Catalog #: 97-1002P018 Size: 2 vials

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Biological Information
Background Information:	The KILR® SKBR3 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of SKBR3 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR® cell pool. This stable cell pool is provided as two vials of cryopreserved cells.
Target Name:	SKBR3
Target Species:	Human
Cell Background:	SK-BR-3

Usage
Product Type:	Cell Pool
Application:	Cytotoxicity
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Cytotoxicity
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	KILR®