KILR® Hut78 Cell Pool

The KILR® Hut78 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments via ADCC, CDC, and ADCP

Catalog #: 97-1024P037 Size: 2 vials
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Biological Information
Background Information:
The KILR® Hut78 Cell Pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of Hut78 cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR® cell pool. This stable cell pool is provided as two vials of cryopreserved cells.
Target Name:
Hut78
Target Species:
Human
Cell Background:
Hut78
Usage
Product Type:
Cell Pool
Application:
Cytotoxicity
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Cytotoxicity
Detection Method:
Chemiluminescence
Clinical Relevance
Therapeutic Area:
Oncology/Immuno-Oncology
Additional Information
Brand:
KILR®

User Manuals & Protocols

70-338 KILR Assay for Suspension Cell Lines REV4 User Manual

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Datasheets

97-1024P037

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