KAT2A (GCN5L2)

Background Information:

KAT2A, also known as GCN5L2 (general control of amino acid synthesis protein 5-like 2), is an epigenetic protein that functions as a histone acetyltransferase (HAT). It is responsible for adding acetyl groups to specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression.
KAT2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression.
Aberrant KAT2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. KAT2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.

Target Class:

Epigenetic

Family:

Histone Acetyltransferase (HAT)

Sub Family:

Writer

Protein Name:

GCN5L2

Protein Aliases:

General control of amino acid synthesis protein 5-like 2|Histone acetyltransferase GCN5|hGCN5|Histone succinyltransferase KAT2A|Lysine acetyltransferase 2A|STAF97

Accession Number:

NM_021078.3

UniProt Number:

Q92830

Gene Name:

KAT2A

Gene ID:

2648

Gene Aliases:

GCN5|PCAF-b

Target Species:

Human