JNK3/SAPK1b, unactive

Background Information:

INK3, also known as SAPK 1b (Stress-Activated Protein Kinase 1b), is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. The JNK3 protein sequence is identical to the human JNK3/SAPK1b described in GenBank NM_138980. The DNA sequence, however, is more closely related to the rat cDNA described in GenBank NM_012806.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

JNK3

Protein Aliases:

MAPK 10|MAP kinase p49 3F12|Stress-activated protein kinase 1b|SAPK1b|Stress-activated protein kinase JNK3|c-Jun N-terminal kinase 3

Accession Number:

NM_002753.2; NM_138980.1; NM_138981.1; NM_138982.1

UniProt Number:

P53779

Gene Name:

MAPK10

Gene ID:

5602

Gene Aliases:

JNK3|p493F12|p54bSAPK|JNK3A|PRKM10|SAPK1B

Target Species:

Human