| Biological Information | |
|---|---|
| Background Information: | INK3, also known as SAPK 1b (Stress-Activated Protein Kinase 1b), is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway.
The JNK3 protein sequence is identical to the human JNK3/SAPK1b described in GenBank NM_138980. The DNA sequence, however, is more closely related to the rat cDNA described in GenBank NM_012806. |
| Target Class: | Kinase |
| Family: | Ser/Thr Kinase; MAPK; JNK subfamily |
| Accession Number: | NM_002753.2; NM_138980.1; NM_138981.1; NM_138982.1 |
| Target Name: | JNK3/SAPK1b |
| Target Aliases: | MAPK10, JNK3A, p54bSAPK, PRKM10, FLJ12099, JNK3, FLJ33785, MGC50974, p493F12 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
JNK3/SAPK1b, unactive
N-terminal 6His-tagged recombinant, human JNK3/SAPK1b.
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