JNK3/SAPK1b, active

Background Information:

c-Jun N-terminal kinases (JNKs), a stress-activated protein kinase (SAPK), is involved in cellular responses to environmental stresses. JNK kinases can be activated by stimuli such as UV light, radiation, protein synthesis inhibitors, ceramide, DNA-damaging drugs, chemopreventive drugs, TNF-a, and interleukin 1. JNK binds to an NH2-terminal region of ATF2 and c-Jun and phosphorylates two sites within the activation domain of each transcription factor. Three JNK genes (Jnk1, -2 and -3) have been identified in humans; however, splice variants result in a total of 10 isoforms. Inhibition of JNK3 (MAPK10, Mitogen-activated protein kinase 10, Stress-activated protein kinase JNK3) may provide clinical benefit in diseases as diverse as immune inflammatory (joint, bowel, pulmonary), ischemic injury (brain, cardiac) and neurodegenerative (Alzheimer's, Parkinson's) diseases.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

JNK3

Protein Aliases:

MAPK 10|MAP kinase p49 3F12|Stress-activated protein kinase 1b|SAPK1b|Stress-activated protein kinase JNK3|c-Jun N-terminal kinase 3

Accession Number:

NM_002753.2; NM_138980.1; NM_138981.1; NM_138982.1

UniProt Number:

P53779

Gene Name:

MAPK10

Gene ID:

5602

Gene Aliases:

JNK3|p493F12|p54bSAPK|JNK3A|PRKM10|SAPK1B

Target Species:

Human