JNK1alpha1/SAPK1c, active

Background Information:

c-Jun N-terminal kinases (JNKs), a stress-activated protein kinase (SAPK), is involved in cellular responses to environmental stresses. JNK kinases can be activated by stimuli such as UV light, radiation, protein synthesis inhibitors, ceramide, DNA-damaging drugs, chemopreventive drugs, TNF-a, and interleukin 1. JNK binds to an NH2-terminal region of ATF2 and c-Jun and phosphorylates two sites within the activation domain of each transcription factor. Three JNK genes (Jnk1, -2 and -3) have been identified in humans; however, splice variants result in a total of 10 isoforms. Therapeutic inhibition of JNK may provide clinical benefit in disease as diverse as immune inflammatory (joint, bowel, pulmonary), ischemic injury (brain, cardiac) and neurodegenerative (Alzheimer's, Parkinson's) diseases. EMBL L26318

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

JNK1

Protein Aliases:

JUN N-terminal kinase

Accession Number:

NM_002750.2; NM_139046.1; NM_139047.1; NM_139049.1

UniProt Number:

P45983

Gene Name:

MAPK8

Gene ID:

5599

Gene Aliases:

JNK|JNK1|SAPK1|PRKM8|SAPK1C

Target Species:

Human