| Biological Information | |
|---|---|
| Background Information: | JMJD3 (Jumonji domain-containing protein 3), also known as KDM6B, is a histone demethylase that belongs to the JmjC domain-containing protein family. JMJD3 specifically targets tri-methylated lysine 27 on histone H3 (H3K27me3), and catalyzes its removal, leading to changes in chromatin structure and gene expression. JMJD3 is expressed in a variety of tissues and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis.
JMJD3 has been identified as a potential therapeutic target for various diseases, including cancer, inflammation, and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer. Therefore, JMJD3 is an important epigenetic protein with potential therapeutic applications. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | JMJD3 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
JMJD3
Recombinant, human JMJD3 amino acids 1141-1641.
Datasheets
EPI034 Datasheet
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