JMJD3

Background Information:

JMJD3 (Jumonji domain-containing protein 3), also known as KDM6B, is a histone demethylase that belongs to the JmjC domain-containing protein family. JMJD3 specifically targets tri-methylated lysine 27 on histone H3 (H3K27me3), and catalyzes its removal, leading to changes in chromatin structure and gene expression. JMJD3 is expressed in a variety of tissues and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis.
JMJD3 has been identified as a potential therapeutic target for various diseases, including cancer, inflammation, and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in various types of cancer. Therefore, JMJD3 is an important epigenetic protein with potential therapeutic applications.

Target Class:

Epigenetic

Family:

Histone Demethylase

Sub Family:

Eraser

Protein Name:

JMJD3

Accession Number:

NM_001348716.2

UniProt Number:

O15054

Gene Name:

KDM6B

Gene ID:

23135

Gene Aliases:

KIAA0346

Target Species:

Human