JMJD2A

Background Information:

JMJD2A (Jumonji domain-containing protein 2A) is an epigenetic protein that functions as a histone demethylase. It is responsible for removing methyl groups from specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. JMJD2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant JMJD2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. JMJD2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.

Target Class:

Epigenetic

Family:

Histone Demethylase

Sub Family:

Eraser

Protein Name:

JMJD2A

Protein Aliases:

jumonji C domain-containing histone demethylase 3A|tudor domain containing 14A

Accession Number:

NM_014663.3

UniProt Number:

O75164

Gene Name:

KDM4A

Gene ID:

9682

Gene Aliases:

KIAA0677|JHDM3A|TDRD14A

Target Species:

Human