| Biological Information | |
|---|---|
| Background Information: | Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-α/beta and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. |
| Target Class: | Kinase |
| Family: | Cytosolic Tyrosine Kinase |
| Accession Number: | NM_002227 |
| Target Name: | JAK1 |
| Target Aliases: | JAK1, JTK3, JAK1A, JAK1B |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
JAK1, active
10 µg of active JAK1. N-terminal GST-tagged recombinant, human JAK1 amino acids 866-end. Activated in vitro by auto-phosphorylation.
Datasheets
14-918x Datasheet
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