| Biological Information | |
|---|---|
| Background Information: | IRE1 (Inositol-requiring enzyme 1) is a transmembrane protein kinase that is involved in the endoplasmic reticulum (ER) stress response pathway. It is a key regulator of the unfolded protein response (UPR), which is activated in response to ER stress to maintain ER homeostasis and promote cell survival.
Research has suggested that IRE1 plays a role in several diseases, including cancer, diabetes, and neurodegenerative diseases. In cancer, activation of IRE1 has been shown to promote cell survival and tumor growth, and inhibition of IRE1 has been suggested as a potential cancer therapy. In diabetes, activation of IRE1 has been implicated in the development of insulin resistance and beta cell dysfunction. Additionally, IRE1 has been implicated in the regulation of neuronal survival and degeneration, making it a potential target for the treatment of neurodegenerative diseases. |
| Target Class: | Kinase |
| Accession Number: | NM_001433 |
| Target Name: | IRE1 |
| Target Aliases: | ERN1, IRE1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
IRE1, active
10 µg of active IRE1. N-terminal 6His-tagged recombinant, human IRE1 amino acids 465-end.
Datasheets
14-930x Datasheet
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