IRAK1, active

N-terminal 6His-tagged recombinant, human IRAK1 amino acids 194-end.

Catalog #: 14-684


Biological Information
Background Information:
IRAK (IL-1 Receptor Associated Kinase 1) is a Ser/Thr kinase which associates with the IL-1 Receptor subunits after IL-1 binding, by virtue of the adapter protein MyD88. Three IRAK molecules, IRAK1, IRAK2, and IRAK-M, can relay the NF-&kB-activating signal via TNFR-associated factor 6 (TRAF6) and TGF-b-activated kinase 1 to the IKK complex, which ultimately mediates NF-&kB activation. Inhibition of IRAK1 may reduce inflammation as well as apoptosis. GenBank NM_001569
Target Class:
Accession Number:
NM_001025242.1; NM_001025243.1; NM_001569.3
Target Name:
Target Aliases:
IRAK1, IRAK, IRAK-1, pelle
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-684x Datasheet

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