InCELL Hunter™ Jurkat RIPK3 Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ Jurkat RIPK3 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK3 via detection of RIPK3 levels. This product uses EFC technology. The cell line included overexpresses RIPK3 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

RIPK3

Protein Aliases:

RIP-like protein kinase 3|Receptor-interacting protein 3|RIP-3

Accession Number:

NM_006871.3

UniProt Number:

Q9Y572

Gene Name:

RIPK3

Gene ID:

11035

Gene Aliases:

RIP3

Target Species:

Human

Cell Background:

Jurkat