InCELL Hunter™ HEK 293 SMARCA4 Bromodomain Cell Line

Background Information:

The InCELL Hunter™ HEK 293 SMARCA4 Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of SMARCA4 via detection of SMARCA4 levels. This product uses EFC technology. The cell line included overexpresses SMARCA4 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Bromodomain-Containing

Sub Family:

Reader

Protein Name:

SMARCA4

Protein Aliases:

SNF2-like 4|global transcription activator homologous sequence|sucrose nonfermenting-like 4|mitotic growth and transcription activator|BRM/SWI2-related gene 1|homeotic gene regulator|nuclear protein GRB1|brahma protein-like 1|ATP-dependent helicase SMARCA4

Accession Number:

NM_001128844

UniProt Number:

P51532

Gene Name:

SMARCA4

Gene ID:

6597

Gene Aliases:

hSNF2b|BRG1|BAF190|SNF2|SWI2|SNF2-BETA|SNF2LB|FLJ39786|BAF190A|SNF2B|SNF2L4

Target Species:

Human

Cell Background:

HEK293