InCELL Hunter™ HEK 293 CLK1 Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ HEK 293 CLK1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of CLK1 via detection of CLK1 levels. This product uses EFC technology. The cell line included overexpresses CLK1 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

CLK1

Protein Aliases:

CDC-like kinase 1

Accession Number:

NC_000002.12

UniProt Number:

P49759

Gene Name:

CLK1

Gene ID:

1195

Target Species:

Human

Cell Background:

HEK293