InCELL Hunter™ HEK 293 BRD4(1) Bromodomain Cell Line

Background Information:

The InCELL Hunter™ HEK 293 BRD4(1) Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of BRD4(1) via detection of BRD4(1) levels. This product uses EFC technology. The cell line included overexpresses BRD4(1) target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Bromodomain-Containing

Sub Family:

Reader

Protein Name:

BRD4

Protein Aliases:

chromosome-associated protein

Accession Number:

NM_058243

UniProt Number:

O60885

Gene Name:

BRD4

Gene ID:

23476

Gene Aliases:

HUNKI|MCAP|CAP|HUNK1

Target Species:

Human

Cell Background:

HEK293