InCELL Hunter™ HEK 293 BAZ2A Bromodomain Cell Line

The InCELL Hunter™ HEK 293 BAZ2A Bromodomain Cell Line measures target engagement via compound-induced stabilization of BAZ2A target protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 96-0074C1 Size: 2 vials

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Biological Information
Background Information:	The InCELL Hunter™ HEK 293 BAZ2A Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of BAZ2A via detection of BAZ2A levels. This product uses EFC technology. The cell line included overexpresses BAZ2A target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Epigenetic Protein
Family:	Bromodomain
Sub Family:	Reader
Accession Number:	NM_013449.3
Target Name:	BAZ2A
Target Aliases:	bromodomain adjacent to zinc finger domain, 2A, TIP5, WALp3
Target Species:	Human
Cell Background:	HEK293

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Target Engagement
Detection Method:	Chemiluminescence

Additional Information
Brand:	InCELL Hunter™