InCELL Hunter™ A549 PRMT3 Methyltransferase Cell Line

The InCELL Hunter™ A549 PRMT3 Methyltransferase Cell Line measures target engagement via compound-induced stabilization of PRMT3 target protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 96-0072C15 Size: 2 vials
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Biological Information
Background Information:
The InCELL Hunter™ A549 PRMT3 Methyltransferase Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of PRMT3 via detection of PRMT3 levels. This product uses EFC technology. The cell line included overexpresses PRMT3 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Epigenetic Protein
Family:
Histone methyltransferase
Sub Family:
Writer
Accession Number:
NM_005788.3
Target Name:
PRMT3
Target Aliases:
Protein arginine N-methyltransferase 3
Target Species:
Human
Cell Background:
A549
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Target Engagement
Detection Method:
Chemiluminescence
Additional Information
Brand:
InCELL Hunter™

User Manuals & Protocols

70-400 InCELL Hunter Target Engagement Cell Lines REV0 User Manual

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Datasheets

96-0072C15 Datasheet

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