InCELL Hunter™ A549 G9a Methyltransferase Cell Line

Background Information:

The InCELL Hunter™ A549 G9a Methyltransferase Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of G9a via detection of G9a levels. This product uses EFC technology. The cell line included overexpresses G9a target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Epigenetic

Family:

Histone Methyltransferase (HMT)

Sub Family:

Writer

Protein Name:

G9A

Protein Aliases:

Euchromatic histone-lysine N-methyltransferase 2|HLA-B-associated transcript 8|Histone H3-K9 methyltransferase 3|H3-K9-HMTase 3|Lysine N-methyltransferase 1C|Protein G9a

Accession Number:

NM_006709

UniProt Number:

Q96KQ7

Gene Name:

EHMT2

Gene ID:

10919

Gene Aliases:

G9A|Em:AF134726.3|NG36/G9a|KMT1C

Target Species:

Human

Cell Background:

A549