InCELL Hunter™ A549 CSNK1D Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ A549 CSNK1D Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of CSNK1D via detection of CSNK1D levels. This product uses EFC technology. The cell line included overexpresses CSNK1D target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

CK1

Sub Family:

Protein Ser/Thr

Protein Name:

CK1delta

Protein Aliases:

CKId|Tau-protein kinase CSNK1D

Accession Number:

NC_000017.11

UniProt Number:

P48730

Gene Name:

CSNK1D

Gene ID:

1453

Gene Aliases:

HCKID|CKID|CKIdelta

Target Species:

Human

Cell Background:

A549