InCELL Hunter™ A549 CSF1R Kinase Binding Cell Line

Background Information:

The InCELL Hunter™ A549 CSF1R Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of CSF1R via detection of CSF1R levels. This product uses EFC technology. The cell line included overexpresses CSF1R target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

Fms (CSFR)

Protein Aliases:

CSF-1-R|CSF-1R|M-CSF-R|Proto-oncogene c-Fms|CD antigen CD115

Accession Number:

NC_000005.10

UniProt Number:

P07333

Gene Name:

CSF1R

Gene ID:

1436

Gene Aliases:

C-FMS|CSFR|CD115

Target Species:

Human

Cell Background:

A549