IGF-IR (delta1-958), active

Background Information:

Insulin-like growth factor (IGF) binding to the IGF receptors initiates an intracellular signaling cascade that leads to changes in gene expression and cell biology. Although multiple receptors for the IGFs have been identified, the IGFs primarily exert their biologic effects through ligation of the IGF1R (type I IGF receptor tyrosine kinase, JTK13). IGF1R exerts mitogenic, cell survival, and insulin-like activities, is involved in postnatal growth physiology, and is connected to proliferative disorders such as breast cancer. GenBank X04434

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

IGF1R

Protein Aliases:

Insulin-like growth factor I receptor|IGF-I receptor|CD antigen CD221 [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Accession Number:

NM_000875.3

UniProt Number:

P08069

Gene Name:

IGF1R

Gene ID:

3480

Gene Aliases:

JTK13|CD221|IGFIR|MGC18216|IGFR

Target Species:

Human