| Biological Information | |
|---|---|
| Background Information: | hPHF8 (plant homeodomain finger protein 8) is a histone demethylase that belongs to the PHF (plant homeodomain finger) family. hPHF8 specifically targets tri-methylated lysine 9 and 27 on histone H3 (H3K9me3 and H3K27me3, respectively), and catalyzes their removal, leading to changes in chromatin structure and gene expression.
hPHF8 has been implicated in the regulation of several diseases, including cancer, intellectual disability, and cleft lip and palate. Mutations in the PHF8 gene have been associated with cases of X-linked mental retardation and various developmental disorders. hPHF8 has also been shown to play a role in the regulation of androgen receptor signaling, which is involved in the development and progression of prostate cancer.
hPHF8 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve response to chemotherapy in prostate cancer. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | hPHF8 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
hPHF8
N-terminal 6His-tagged recombinant amino acids 79-447, human PHF8.
Datasheets
EPI049 Datasheet
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