HIPK4 (Homeodomain Interacting Protein Kinase 4) is a serine/threonine protein kinase that belongs to the HIPK (Homeodomain Interacting Protein Kinase) family of kinases. It is involved in the regulation of a variety of cellular processes, including transcriptional regulation, cell proliferation, and apoptosis. Research has suggested that HIPK4 plays a role in several diseases, including cancer and developmental disorders. In cancer, HIPK4 has been shown to promote tumor cell survival and proliferation, and alterations in HIPK4 expression and activity have been observed in various types of cancer. Additionally, HIPK4 has been implicated in the regulation of neural development and has been linked to developmental disorders such as autism spectrum disorder. HIPK4 has also been suggested as a potential therapeutic target in cancer, and efforts to develop small-molecule inhibitors of the kinase are underway.
Drug Discovery & Development
1 year at -70°C
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C-terminal 6His tagged, recombinant, human HIPK4 full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography.