HIPK2, active

N-terminal 6His-tagged recombinant, human HIPK2 amino acids 165-564.

Catalog #: 14-623


Biological Information
Background Information:
Homeodomain-interacting protein kinase 2 (HIPK2), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK2 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK2 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK2 may inhibit apoptosis and facilitate tumorigenesis. GenBank AF326592. The recombinant protein contains the amino acid substitution I471N (native coordinates) with respect to GenBank AF326592. This conflict is reported in GenBank accession nos. AF207702, AF208291, NM022740.
Target Class:
Accession Number:
Target Name:
Target Aliases:
HIPK2, PRO0593, hHIPk2
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.


14-623x Datasheet

View Document