Biological Information

Background Information:

Homeodomain-interacting protein kinase 2 (HIPK2), a serine/threonine kinase, has been described as a member of a family of nuclear kinases that act as co-repressors for homeodomain transcription factors. HIPK2 can activate p53-mediated transcriptional regulation of MDM2 and antagonize Myc/Ras-induced transformation. HIPK2 may play an important role in the regulation of p53 apoptotic function. Inhibition of HIPK2 may inhibit apoptosis and facilitate tumorigenesis. GenBank AF326592. The recombinant protein contains the amino acid substitution I471N (native coordinates) with respect to GenBank AF326592. This conflict is reported in GenBank accession nos. AF207702, AF208291, NM022740.

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

HIPK2

Accession Number:

NM_022740.2

UniProt Number:

Q9H2X6

Gene Name:

HIPK2

Gene ID:

28996

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology