HAT1

Background Information:

HAT1 (histone acetyltransferase 1) is an enzyme that adds acetyl groups to histone proteins. Histones are the proteins that package DNA into chromatin, and acetylation is a type of post-translational modification that can modify the structure of chromatin and influence gene expression. Specifically, acetylation of histones is associated with a more open chromatin structure that allows for greater access to DNA by transcription factors and other proteins, leading to increased gene expression.
HAT1 is conserved across a wide range of organisms, from yeast to humans, and has been shown to play an important role in various cellular processes, including DNA replication, repair, and cell cycle regulation. Dysregulation of HAT1 has been linked to various diseases, including cancer and neurological disorders. Therefore, HAT1 has emerged as a potential target for therapeutic interventions.

Target Class:

Epigenetic

Family:

Histone Acetyltransferase (HAT)

Sub Family:

Writer

Protein Name:

HAT1

Accession Number:

NM_003642.4

UniProt Number:

O14929

Gene Name:

HAT1

Gene ID:

8520

Gene Aliases:

KAT1

Target Species:

Human