GRK3, active

Background Information:

GRK3, G protein-coupled receptor kinase 3, is a beta-adrenergic receptor kinase that specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

GRK3

Protein Aliases:

G-protein-coupled receptor kinase 3

Accession Number:

NM_005160.4

UniProt Number:

P35626

Gene Name:

GRK3

Gene ID:

157

Gene Aliases:

ADRBK2|BARK2

Target Species:

Human