Flt-3, active

Background Information:

The receptor tyrosine kinase FLT-3 (fms-related tyrosine kinase 3, STK1) appears to play an important role in the development of hematopoietic stem cells, dendritic cells, B progenitor cells, and natural killer (NK) cells. On binding FLT3 ligand, the wild-type receptor dimerizes, activating its tyrosine kinase domain with resultant autophosphorylation. RAS-GAP, PLC-g, PI3-kinase, STAT5, and ERK1/2 are important signaling proteins linked to activation of FLT3. FLT3 is aberrantly expressed in the malignant cells in the majority of patients with acute myeloid leukemia (AML). GenBank NM_004119

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

FLT3

Protein Aliases:

FL cytokine receptor|Fetal liver kinase-2|FLK-2|Fms-like tyrosine kinase 3|FLT-3|Stem cell tyrosine kinase 1|STK-1|CD antigen CD135

Accession Number:

NM_004119.2

UniProt Number:

P36888

Gene Name:

FLT3

Gene ID:

2322

Gene Aliases:

STK1|FLK2|CD135

Target Species:

Human