FGFR1, active

Background Information:

Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGFR1 through FGFR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. Overexpression and amplification of the fibroblast growth factor receptor-1 (FGFR-1), a prototypic receptor tyrosine kinase, have been found in tumor samples from human pancreas, breast, brain, prostate, thyroid gland, and salivary gland. GenBank NM_000604

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

FGFR1

Protein Aliases:

Pfeiffer syndrome

Accession Number:

NM_000604.2

UniProt Number:

P11362

Gene Name:

FGFR1

Gene ID:

2260

Gene Aliases:

H2|H3|H4|H5|CEK|FLG|BFGFR|N-SAM|CD331

Target Species:

Human