FAK, active

Background Information:

PTK2 (Protein Tyrosine Kinase 2, formerly FAK or Focal Adhesion Associated Protein Tyrosine Kinase) is a widely expressed non-receptor involved in the structure and function of focal adhesions, which are critical for cellular integrity by maintaining cell-cell and cell-matrix interactions. Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine phosphorylation of PTK2. Autophosphorylation of PTK2 leads to the binding of SH2-domain proteins including Src-family kinases and the Grb2-Sos complex, then activate Ras cascade and ultimately to mitogen activated protein (MAP) kinase activation. GenBank L13616

Target Class:

Kinase

Family:

TK

Sub Family:

Protein Tyrosine

Protein Name:

FAK

Protein Aliases:

protein phosphatase 1, regulatory subunit 71

Accession Number:

NM_005607.3; NM_153831.2

UniProt Number:

Q05397

Gene Name:

PTK2

Gene ID:

5747

Gene Aliases:

FAK|FADK|FAK1|PPP1R71

Target Species:

Human