| Biological Information | |
|---|---|
| Background Information: | Human EGF receptor 2 (HER2, ERBB2) tyrosine kinase is an EGF receptor-related protein tyrosine kinase which is overexpressed in many mammary and ovarian carcinomas. Binding of the ligand to the receptor is believed to activate the receptor's intrinsic protein kinase activity, initiating a signal transduction pathway which leads to increased cell proliferation. Truncated HER2, lacking the extracellular and transmembrane regions, is constitutively active. The active kinase transfers g-phosphates of ATP to the phenolic hydroxyl of specific tyrosine residues on target proteins.
GenBank NM_004448 |
| Target Class: | Kinase |
| Family: | Receptor Typosine Kinase (RTK): Growth Factor Receptor |
| Accession Number: | NM_004448; G778D |
| Target Name: | ErbB2 |
| Target Aliases: | ERBB2HER2NGLNEUHER-2TKR1MLN19 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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ErbB2, active
10 µg of active ErbB2. C-terminal 6His-tagged recombinant, human ErbB2 amino acids 676-end.
Datasheets
14-939x Datasheet
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