Eph family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. Expression of the EPB4 (EphB4, Ephrin type-B receptor 4, Tyrosine-protein kinase receptor HTK, EC 18.104.22.168) receptors and their ephrinB ligands play a key role in normal vascular formation as well as in diabetic retinopathy, malignant tumor progression and angiogenesis. Inhibition of EPB4 may be used in the treatment of diabetic renopathy and angioproliferative tumors. GenBank AY056047
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Drug Discovery & Development
6 months at -70°C
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