EphB1, active

Background Information:

Eph (erythropoietin-producing hepatocellular) family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. EphB1 (EPHT2, NET, Hek6, ELK) is expressed predominantly in developing neural structures in embryos, in vascular epithelium of kidney and other tissues. EphB1 signals regulation of cell attachment and cell-cell assembly and are implicated in neuronal and vascular cell targeting. GenBank NM_004441

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphB1

Protein Aliases:

ELK|EPH tyrosine kinase 2|EPH-like kinase 6|EK6|hEK6|Neuronally-expressed EPH-related tyrosine kinase|NET|Tyrosine-protein kinase receptor EPH-2

Accession Number:

NM_004441.3

UniProt Number:

P54762

Gene Name:

EPHB1

Gene ID:

2047

Gene Aliases:

Hek6

Target Species:

Human