Biological Information

Background Information:

Eph (erythropoietin-producing hepatocellular) family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. Among them, only EphA4 can cross-respond to both ephrin-A and -B. EphA5 (EHK1, HEK7, CEK7, TYRO4) is widely distributed in CNS. The localization of EphA5 to motor and sensory neurons is consistent with a role of EphA5 in neural plasticity, cell-cell recognition, and topographical orientation of neuronal systems. GenBank NM_004439

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

EphA5

Protein Aliases:

Brain-specific kinase|EPH homology kinase 1|EHK-1|EPH-like kinase 7|EK7|hEK7

Accession Number:

NM_004439.4; NM_182472.1

UniProt Number:

P54756

Gene Name:

EPHA5

Gene ID:

2044

Gene Aliases:

Hek7|TYRO4|CEK7|EHK1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology