Eph (erythropoietin-producing hepatocellular) family tyrosine kinase receptors consist of two groups: EphA group members respond to ephrin-A, which is anchored to the cell membrane by glycosylphosphatidylinositol, whereas EphB group members respond to ephrin-B, containing a transmembrane domain. High levels of EphA2 have been documented in many cell models and clinical specimens of human cancer, including metastatic melanoma and breast, prostate, lung, renal cell, colon, and esophageal carcinomas. GenBank NM_00431
Receptor Typosine Kinase (RTK): Growth Factor Receptor
Drug Discovery & Development
6 months at -70°C
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