Biological Information

Background Information:

DDR2 is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may also be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

DDR2

Protein Aliases:

CD167 antigen-like family member B|Discoidin domain-containing receptor tyrosine kinase 2|Neurotrophic tyrosine kinase, receptor-related 3|Receptor protein-tyrosine kinase TKT|Tyrosine-protein kinase TYRO10|CD antigen CD167b

Accession Number:

NM_001014796.1; NM_006182.2

UniProt Number:

Q16832

Gene Name:

DDR2

Gene ID:

4921

Gene Aliases:

TKT

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

6 months at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology