CHO-K1 PTGFR Gq Cell Line

Background Information:

The PTGFR Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin F2a) based activation of PTGFR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGFR , a naturally Gq coupled GPCR. Upon activation of PTGFR , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Prostanoid

Sub Family:

Class A

Coupling:

Gq

Protein Name:

FP

Protein Aliases:

PGF2-alpha receptor|Prostanoid FP receptor

Accession Number:

NM_000959.3

UniProt Number:

P43088

Gene Name:

PTGFR

Gene ID:

5737

Gene Aliases:

FP

Target Species:

Human

Cell Background:

CHO-K1