ChemiSCREEN™ SUCNR1/GPR91 Succinate Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ SUCNR1/GPR91 Succinate Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. succinate) based activation of SUCNR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SUCNR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SUCNR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Succinate

Sub Family:

Class A

Protein Name:

SUCNR1 (GPR91)

Accession Number:

NM_033050

UniProt Number:

Q9BXA5

Gene Name:

SUCNR1

Gene ID:

56670

Target Species:

Human

Cell Background:

Chem-1