ChemiSCREEN™ S1P2 Lysophospholipid Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ S1P2 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. S1P) based activation of S1PR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses S1PR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of S1PR2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Lysophospholipid (S1P)

Sub Family:

Class A

Protein Name:

S1P2

Protein Aliases:

EDG5|Endothelial differentiation G-protein coupled receptor 5|Sphingosine 1-phosphate receptor Edg-5|S1P receptor Edg-5

Accession Number:

NM_004230

UniProt Number:

O95136

Gene Name:

S1PR2

Gene ID:

9294

Gene Aliases:

Gpcr13|H218|AGR16

Target Species:

Human

Cell Background:

Chem-1